Androgen deprivation therapy and cataract incidence among elderly prostate cancer patients in the United States.

ABSTRACT:

Purpose

The side-effects associated with androgen deprivation therapy (ADT) include weight gain, dyslipidemia, and insulin resistance. As cataracts have been linked to these metabolic abnormalities, an increased risk of cataract may be another adverse consequence of ADT use.

Methods

Using data from the Surveillance, Epidemiology and End Results-Medicare database, we estimated risk of cataract associated with ADT among 65,852 prostate-cancer patients. ADT treatment was defined as at least one dose of a gonadotropin-releasing hormone agonist or orchiectomy within 6 months after prostate cancer diagnosis. The outcome measure was a first claim of cataract diagnosis identified in Medicare claim files. Cox regression was used to estimate hazard ratios (HR) for the effects of ADT t

SUBMITTER: Beebe-Dimmer J 

PROVIDER: S-EPMC3792579 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature