Identification of novel vaccine candidates against multidrug-resistant Acinetobacter baumannii.

ABSTRACT: Acinetobacter baumannii is an emerging opportunistic bacterium associated with nosocomial infections in intensive care units. The alarming increase in infections caused by A. baumannii is strongly associated with enhanced resistance to antibiotics, in particular carbapenems. This, together with the lack of a licensed vaccine, has translated into significant economic, logistic and health impacts to health care facilities. In this study, we combined reverse vaccinology and proteomics to identify surface-exposed and secreted antigens from A. baumannii. Using in silico prediction tools and comparative genome analysis in combination with in vitro proteomic approaches, we identified 42 antigens that could be used as potential vaccine targets. Considering the paucity of effective antibiotics avai

SUBMITTER: Moriel DG 

PROVIDER: S-EPMC3792912 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature