Dysregulation of complement system and CD4+ T cell activation pathways implicated in allergic response.

ABSTRACT: Allergy is a complex disease that is likely to involve dysregulated CD4+ T cell activation. Here we propose a novel methodology to gain insight into how coordinated behaviour emerges between disease-dysregulated pathways in response to pathophysiological stimuli. Using peripheral blood mononuclear cells of allergic rhinitis patients and controls cultured with and without pollen allergens, we integrate CD4+ T cell gene expression from microarray data and genetic markers of allergic sensitisation from GWAS data at the pathway level using enrichment analysis; implicating the complement system in both cellular and systemic response to pollen allergens. We delineate a novel disease network linking T cell activation to the complement system that is significantly enriched for genes exhibiting cor

SUBMITTER: Couto Alves A 

PROVIDER: S-EPMC3792967 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature