Molecular epidemiology and putative origin of hepatitis C virus in random volunteers from Argentina.

ABSTRACT:

Aim

To study the subtype prevalence and the phylogenetic relatedness of hepatitis C virus (HCV) sequences obtained from the Argentine general population, a large cohort of individuals was analyzed.

Methods

Healthy Argentinian volunteers (n = 6251) from 12 provinces representing all geographical regions of the country were studied. All parents or legal guardians of individuals younger than 18 years provided informed written consent for participation. The corresponding written permission from all municipal authorities was obtained from each city or town where subjects were to be included. HCV RNA reverse transcription-polymerase chain reaction products were sequenced and phylogenetically analyzed. The 5' untranslated region (5'UTR) was used for RNA detection and initial genoty

SUBMITTER: del Pino N 

PROVIDER: S-EPMC3793136 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature