ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population.

ABSTRACT:

Aim

To evaluate the association between the genetic polymorphisms and haplotypes of the ITGA1 gene and the risk of gastric cancer.

Methods

The study subjects were 477 age- and sex-matched case-control pairs. Genotyping was performed for 15 single nucleotide polymorphisms (SNPs) in ITGA1. The associations between gastric cancer and these SNPs and haplotypes were analyzed with multivariate conditional logistic regression models. Multiple testing corrections were carried out following methodology for controlling the false discovery rate. Gene-based association tests were performed using the versatile gene-based association study (VEGAS) method.

Results

In the codominant model, the ORs for SNPs rs2432143 (1.517; 95%CI: 1.144-2.011) and rs2447867 (1.258; 95%CI: 1.051-1.505

SUBMITTER: Yim DH 

PROVIDER: S-EPMC3793141 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature