Association between UCP3 gene polymorphisms and nonalcoholic fatty liver disease in Chinese children.

ABSTRACT:

Aim

To confirm the hypothesis that polymorphisms of the uncoupling protein 3 (UCP3) gene are associated with the occurrence of nonalcoholic fatty liver disease (NAFLD).

Methods

A total of 250 NAFLD patients (147 males and 103 females) and 200 healthy individuals who served as controls (control, 109 males and 91 females), aged between 6 and 16 years were enrolled in this study. The four non-synonymous single nucleotide polymorphisms (SNPs) in the UCP3 gene polymorphisms of rs1726745, rs3781907, rs11235972 and rs1800849, were genotyped using MassArray. Body mass index (BMI), waist and hip circumference, blood pressure (BP), fasting blood glucose (FBG), insulin and lipid profiles were measured and B-ultrasound examination was performed in all subjects.

Results

NAFLD pati

SUBMITTER: Xu YP 

PROVIDER: S-EPMC3793144 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature