Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity.

ABSTRACT: Forkhead box P3 (Foxp3)(+) T regulatory (T(reg)) cells maintain immune homeostasis and limit autoimmunity but can also curtail host immune responses to various types of tumors. Foxp3(+) T(reg) cells are therefore considered promising targets to enhance antitumor immunity, and approaches for their therapeutic modulation are being developed. However, although studies showing that experimentally depleting Foxp3(+) T(reg) cells can enhance antitumor responses provide proof of principle, these studies lack clear translational potential and have various shortcomings. Histone/protein acetyltransferases (HATs) promote chromatin accessibility, gene transcription and the function of multiple transcription factors and nonhistone proteins. We now report that conditional deletion or pharmacologic inhib

SUBMITTER: Liu Y 

PROVIDER: S-EPMC3793393 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature