Anti-inflammatory cytokines, pro-fibrogenic chemokines and persistence of acute HCV infection.

ABSTRACT: Chemokines and cytokines play a vital role in directing and regulating immune responses to viral infections. Persistent hepatitis C virus (HCV) infection is characterized by the loss of anti-HCV cellular immune responses, while control of HCV infection is associated with maintenance of anti-HCV cellular immune responses. To determine whether plasma concentrations of 19 chemokines and cytokines controlling T-cell trafficking and function differed based on infection outcome, we compared them in at-risk subjects followed prospectively for HCV infection. Levels were compared over time in subjects who controlled HCV infection (Clearance) and subjects who developed persistent HCV infection (Persistence) at two time points during acute infection: (i) first viraemic sample (initial viraemia) and (

SUBMITTER: Osburn WO 

PROVIDER: S-EPMC3793396 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature