Orthotopic xenografts of RCC retain histological, immunophenotypic and genetic features of tumours in patients.

ABSTRACT: Renal cell carcinoma (RCC) is an aggressive malignancy with limited responsiveness to existing treatments. In vivo models of human cancer, including RCC, are critical for developing more effective therapies. Unfortunately, current RCC models do not accurately represent relevant properties of the human disease. The goal of this study was to develop clinically relevant animal models of RCC for preclinical investigations. We transplanted intact human tumour tissue fragments orthotopically in immunodeficient mice. The xenografts were validated by comparing the morphological, phenotypic and genetic characteristics of the kidney tumour tissues before and after implantation. Twenty kidney tumours were transplanted into mice. Successful tumour growth was detected in 19 cases (95%). The histopathol

SUBMITTER: Grisanzio C 

PROVIDER: S-EPMC3793840 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature