Global identification of conserved post-transcriptional regulatory programs in trypanosomatids.

ABSTRACT: While regulatory programs are extensively studied at the level of transcription, elements that are involved in regulation of post-transcriptional processes are largely unknown, and methods for systematic identification of these elements are in early stages. Here, using a novel computational framework, we have integrated sequence information with several functional genomics data sets to characterize conserved regulatory programs of trypanosomatids, a group of eukaryotes that almost entirely rely on post-transcriptional processes for regulation of mRNA abundance. This analysis revealed a complex network of linear and structural RNA elements that potentially govern mRNA abundance across different life stages and environmental conditions. Furthermore, we show that the conserved regulatory netw

SUBMITTER: Najafabadi HS 

PROVIDER: S-EPMC3794602 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature