Concordance of gene expression in human protein complexes reveals tissue specificity and pathology.

ABSTRACT: Disease-causing variants in human genes usually lead to phenotypes specific to only a few tissues. Here, we present a method for predicting tissue specificity based on quantitative deregulation of protein complexes. The underlying assumption is that the degree of coordinated expression among proteins in a complex within a given tissue may pinpoint tissues that will be affected by a mutation in the complex and coordinated expression may reveal the complex to be active in the tissue. We identified known disease genes and their protein complex partners in a high-quality human interactome. Each susceptibility gene's tissue involvement was ranked based on coordinated expression with its interaction partners in a non-disease global map of human tissue-specific expression. The approach demonstrat

SUBMITTER: Bornigen D 

PROVIDER: S-EPMC3794609 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature