Oxidative stress and epigenetic regulation in ageing and age-related diseases.

ABSTRACT: Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available. To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. Mechanistically, it is well accepted that the accumulation of intracellular damage determined by reactive oxygen species (ROS) might orchestrate the progressive loss of control over biological homeostasis and the functional impairment typical of aged tissues. Here, we review how epigenetics takes part in the

SUBMITTER: Cencioni C 

PROVIDER: S-EPMC3794746 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature