AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines.

ABSTRACT:

Background

Gallbladder carcinoma is a highly malignant tumor and a public health problem in some parts of the world. It is characterized by a poor prognosis and its resistance to radio and chemotherapy. There is an urgent need to develop novel therapeutic alternatives for the treatment of gallbladder carcinoma. The mammalian target of the rapamycin (mTOR) signaling pathway is activated in about 50% of human malignancies, and its role in gallbladder carcinoma has previously been suggested. In the present study, we investigated the phosphorylation status of the mTOR substrate p70S6K in preneoplastic and neoplastic gallbladder tissues and evaluated the effect of three mTOR inhibitors on cell growth and migration in gallbladder carcinoma cell lines.

Methods

Immunohistochemical s

SUBMITTER: Leal P 

PROVIDER: S-EPMC3794848 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature