Local apoptosis mediates clearance of macrophages from resolving inflammation in mice.

ABSTRACT: Chronic inflammatory diseases such as atherosclerosis are characterized by an accumulation of macrophages. To design therapies that would reduce macrophage burden during disease, understanding the cellular and molecular mechanisms that regulate macrophage removal from sites of resolving inflammation is critical. Although past studies have considered the local death of macrophages or the possibility that they emigrate out of inflammatory foci, methods to quantify death or emigration have never been employed. Here, we applied quantitative competition approaches and other methods to study resolution of thioglycollate-induced peritonitis, the model in which earlier work indicated that emigration to lymph nodes accounted for macrophage removal. We show that migration to lymph nodes occurred in

SUBMITTER: Gautier EL 

PROVIDER: S-EPMC3795463 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature