Unawareness of motor phenoconversion in Huntington disease.

ABSTRACT:

Objective

To determine whether Huntington disease (HD) mutation carriers have motor symptoms (complaints) when definite motor onset (motor phenoconversion) is diagnosed and document differences between the groups with and without unawareness of motor signs.

Methods

We analyzed data from 550 HD mutation carriers participating in the multicenter PREDICT-HD Study followed through the HD prodrome. Data analysis included demographics, the Unified Huntington's Disease Rating Scale (UHDRS) and the Participant HD History of symptoms, self-report of progression, and cognitive, behavioral, and imaging measures. Unawareness was identified when no motor symptoms were self-reported but when definite motor HD was diagnosed.

Results

Of 38 (6.91%) with onset of motor HD, almost half

SUBMITTER: McCusker EA 

PROVIDER: S-EPMC3795599 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature