Migraine and structural changes in the brain: a systematic review and meta-analysis.

ABSTRACT:

Objective

To evaluate the association between migraine without aura (MO) and migraine with aura (MA) and 3 types of structural brain abnormalities detected by MRI: white matter abnormalities (WMAs), infarct-like lesions (ILLs), and volumetric changes in gray and white matter (GM, WM) regions.

Methods

PubMed as well as the reference lists of identified studies and reviews were used to identify potentially eligible studies through January 2013. Candidate studies were reviewed and eligible studies were abstracted. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated for WMAs and ILLs.

Results

Six population-based and 13 clinic-based studies were identified. The studies suggested that structural brain changes, including WMAs, silent ILLs, and volumetr

SUBMITTER: Bashir A 

PROVIDER: S-EPMC3795609 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature