Large extracellular loop of tetraspanin as a potential vaccine candidate for filariasis.

ABSTRACT: Lymphatic filariasis affects nearly 120 million people worldwide and mass preventive chemotherapy is currently used as a strategy to control this infection. This has substantially reduced the incidence of the infection in several parts of the world. However, a prophylactic vaccine would be more effective in preventing future infections and will supplement the mass chemotherapy efforts. Unfortunately, there is no licensed vaccine available currently to prevent this infection. Molecules expressed on the surface of the parasite are potential candidates for vaccine development as they are exposed to the host immune system. In this study we show that the large extracellular loop of tetraspanin (TSP LEL), a protein expressed on the cuticle of Brugia malayi and Wuchereria bancrofti is a potential

SUBMITTER: Dakshinamoorthy G 

PROVIDER: S-EPMC3795629 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature