F11R is a novel monocyte prognostic biomarker for malignant glioma.

ABSTRACT:

Objective

Brain tumors (gliomas) contain large populations of infiltrating macrophages and recruited microglia, which in experimental murine glioma models promote tumor formation and progression. Among the barriers to understanding the contributions of these stromal elements to high-grade glioma (glioblastoma; GBM) biology is the relative paucity of tools to characterize infiltrating macrophages and resident microglia. In this study, we leveraged multiple RNA analysis platforms to identify new monocyte markers relevant to GBM patient outcome.

Methods

High-confidence lists of mouse resident microglia- and bone marrow-derived macrophage-specific transcripts were generated using converging RNA-seq and microarray technologies and validated using qRT-PCR and flow cytometry. Expre

SUBMITTER: Pong WW 

PROVIDER: S-EPMC3795683 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature