Genome-wide linkage and regional association study of obesity-related phenotypes: the GenSalt study.

ABSTRACT:

Objective

To identify chromosomal regions harboring quantitative trait loci for waist circumference (WC) and body mass index (BMI).

Design and methods

A genome-wide linkage scan and regional association study WC and BMI among 633 Chinese families was conducted.

Results

A significant linkage signal for WC was observed at 22q13.31-22q13.33 in the overall analysis (LOD = 3.13). Follow-up association study of 22q13.31-13.33 revealed an association between the TBC1D22A gene marker rs16996195 and WC (false discovery rate [FDR]-Q < 0.05). In gender-stratified analysis, suggestive linkage signals were attained for WC at 2p24.3-2q12.2 and 22q13.33 among females (LOD = 2.54 and 2.15, respectively). Among males, 6q12-6q13 was suggestively linked to BMI (LOD = 2.03). Single marke

SUBMITTER: Liu AY 

PROVIDER: S-EPMC3795915 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature