Heterogeneity and new epitopes of hepatitis C virus genotype 4.

ABSTRACT:

Background

Hepatitis C virus (HCV) was found to have a major role in human liver disease by its ability to face the host-cell defenses and the immune system. Heterogeneity of HCV was the key for its adaptation to its host and represented a significant hurdle for the development of both effective vaccines as well as for novel therapeutic interventions.

Objectives

Due to the heterogeneity of HCV virus because of both high replication and high mutation rate in vivo, this study was conducted to analyze different isolates of Egyptian patients of genotype 4, of the most mutant regions of the virus (E1 and E2) as they played an important role in viral persistence by escaping from the immune system of the host body.

Patients and methods

This study was conducted through PCR am

SUBMITTER: Omran MH 

PROVIDER: S-EPMC3796197 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature