Polymorphisms in oxidative stress genes, physical activity, and breast cancer risk.

ABSTRACT:

Purpose

The mechanisms driving the physical activity-breast cancer association are unclear. Exercise both increases reactive oxygen species production, which may transform normal epithelium to a malignant phenotype, and enhances antioxidant capacity, which could protect against subsequent oxidative insult. Given the paradoxical effects of physical activity, the oxidative stress pathway is of interest. Genetic variation in CAT or antioxidant-related polymorphisms may mediate the physical activity-breast cancer association.

Methods

We investigated the main and joint effects of three previously unreported polymorphisms in CAT on breast cancer risk. We also estimated interactions between recreational physical activity (RPA) and 13 polymorphisms in oxidative stress-related genes.

SUBMITTER: McCullough LE 

PROVIDER: S-EPMC3796339 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature