Vascular endothelial growth factor gene polymorphisms and renal cell carcinoma: A systematic review and meta-analysis.

ABSTRACT: Renal cell carcinoma (RCC) accounts for 3% of all cancer-related mortalities in adults. The risk factors for the development of RCC remain under investigation. Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis and is crucial for the development and metastasis of tumors, including RCC. VEGF gene polymorphisms may alter VEGF protein concentrations, affect the process of angiogenesis and may be involved in inter-individual variation in carcinogenesis. In the present study, a systematic review and meta-analysis were performed based on published case-control studies in order to estimate the association between VEGF gene polymorphisms and the susceptibility to RCC. A total of five studies that involved eight polymorphisms and were published between January 2000 and Dece

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC3796421 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature