Genomic instability: a stronger prognostic marker than proliferation for early stage luminal breast carcinomas.

ABSTRACT:

Background

The accurate prognosis definition to tailor treatment for early luminal invasive breast carcinoma patients remains challenging.

Materials and methods

Two hundred fourteen early luminal breast carcinomas were genotyped with single nucleotide polymorphisms (SNPs) array to determine the number of chromosomal breakpoints as a marker of genomic instability. Proliferation was assessed by KI67 (immunohistochemistry) and genomic grade index (transcriptomic analysis). IHC3 (IHC4 score for HER2 negative tumors) was also determined.

Results

In the training set (109 cases), the optimal cut-off was 34 breakpoints with a specificity of 0.94 and a sensitivity of 0.57 (Area under the curve (AUC): 0.81[0.71; 0.91]). In the validation set (105 cases), the outcome of patients

SUBMITTER: Vincent-Salomon A 

PROVIDER: S-EPMC3797106 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature