The retinoid-related orphan receptor alpha (RORA) gene and fear-related psychopathology.

ABSTRACT:

Background

This study followed on findings from a recent genome-wide association study of PTSD that implicated the retinoid-related orphan receptor alpha (RORA) gene (Logue et al., 2012) by examining its relationship to broader array of disorders.

Methods

Using data from the same cohort (N=540), we analyzed patterns of association between 606 single nucleotide polymorphisms (SNPs) spanning the RORA gene and comorbidity factors termed fear, distress (i.e., internalizing factors) and externalizing.

Results

Results showed that rs17303244 was associated with the fear component of internalizing (i.e., defined by symptoms of panic, agoraphobia, specific phobia, and obsessive-compulsive disorder) at a level of significance that withstood correction for gene-wide multiple tes

SUBMITTER: Miller MW 

PROVIDER: S-EPMC3797180 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature