Prefrontal cortical dysfunction after overexpression of histone deacetylase 1.

ABSTRACT:

Background

Postmortem brain studies have shown that HDAC1-a lysine deacetylase with broad activity against histones and nonhistone proteins-is frequently expressed at increased levels in prefrontal cortex (PFC) of subjects diagnosed with schizophrenia and related disease. However, it remains unclear whether upregulated expression of Hdac1 in the PFC could affect cognition and behavior.

Methods

Using adeno-associated virus, an Hdac1 transgene was expressed in young adult mouse PFC, followed by behavioral assays for working and long-term memory, repetitive activity, and response to novelty. Prefrontal cortex transcriptomes were profiled by microarray. Antipsychotic drug effects were explored in mice treated for 21 days with haloperidol or clozapine.

Results

Hdac1 overex

SUBMITTER: Jakovcevski M 

PROVIDER: S-EPMC3797203 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature