Induction of caspase 3 activation by multiple Legionella pneumophila Dot/Icm substrates.

ABSTRACT: The intracellular pathogen Legionella pneumophila is able to strike a balance between the death and survival of the host cell during infection. Despite the presence of high level of active caspase 3, the executioner caspase of apoptotic cell death, infected permissive macrophages are markedly resistant to exogenous apoptotic stimuli. Several bacterial molecules capable of promoting the cell survival pathways have been identified, but proteins involved in the activation of caspase 3 remain unknown. To study the mechanism of L. pneumophila-mediated caspase 3 activation, we tested all known Dot/Icm substrates for their ability to activate caspase 3. Five effectors capable of causing caspase 3 activation upon transient expression were identified. Among these, by using its ability to activate c

SUBMITTER: Zhu W 

PROVIDER: S-EPMC3797225 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature