Detecting secondary structure and surface orientation of helical peptide monolayers from resonant hybridization signals.

ABSTRACT: Hybridization of dominant vibrational modes with meta-surface resonance allows detection of both structural changes and surface orientations of bound helical peptides. Depending on the resonance frequency of meta-molecules, a red- or blue- shift in peptide Amide-I frequency is observed. The underlying coupling mechanism is described by using a temporal coupled mode theory that is in very good agreement with the experimental results. This hybridization phenomenon constitutes the basis of many nanophotonic systems such as tunable coupled mode bio-sensors and dynamic peptide systems driven by infrared signals.

SUBMITTER: Alici KB 

PROVIDER: S-EPMC3797430 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature