Tissue-specific transcriptional regulation has diverged significantly between human and mouse.

ABSTRACT: We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41% to 89% of their binding events seem to be species specific. When the same protein binds the promoters of orthologous genes, approximately two-thirds of the binding sites do not align.

SUBMITTER: Odom DT 

PROVIDER: S-EPMC3797512 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature