Relative incidence of inherited white matter disorders in childhood to acquired pediatric demyelinating disorders.

ABSTRACT: Epidemiologic frequencies of pediatric white matter disorders as a class have not been well defined. This is particularly true of genetic disorders of the white matter of the brain. In this study, ICD-9 codes were used to estimate relative incidence rates and descriptive statistics of leukodystrophies, other genetic leukoencephalopathies and acquired demyelinating disease among children residing in the Washington, D.C. metropolitan area. Children being treated at US children's hospitals between January 1, 2004, and December 31, 2009, for acquired demyelinating disease or genetic white matter disorders were captured using the Pediatric Health Information System and the Physician Practice Management system and validated with local electronic medical records. Comparisons were made between gen

SUBMITTER: Vanderver A 

PROVIDER: S-EPMC3797524 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature