Physical origin of the contact frequency in chromosome conformation capture data.

ABSTRACT: Physical proximity between each pair of genomic loci in a nucleus is measured as a form of contact frequency in chromosome conformation capture-based methods. Complexity of chromosome structure in interphase can be characterized by measuring a statistical property of physical distance between genomic loci according to genomic separation along single chromatids. To find a relationship between the physical distance and the contact frequency, we propose a polymer model derived from the Langevin equation. The model is derived by considering a structure of a chromosome as a trajectory of a particle, where each consecutive segment in the chromosome corresponds to a transient position in the trajectory over time. Using chromosome conformation capture data, we demonstrate the functional relationsh

SUBMITTER: Hahn S 

PROVIDER: S-EPMC3797596 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature