Minimizing the average distance to a closest leaf in a phylogenetic tree.

ABSTRACT: When performing an analysis on a collection of molecular sequences, it can be convenient to reduce the number of sequences under consideration while maintaining some characteristic of a larger collection of sequences. For example, one may wish to select a subset of high-quality sequences that represent the diversity of a larger collection of sequences. One may also wish to specialize a large database of characterized "reference sequences" to a smaller subset that is as close as possible on average to a collection of "query sequences" of interest. Such a representative subset can be useful whenever one wishes to find a set of reference sequences that is appropriate to use for comparative analysis of environmentally derived sequences, such as for selecting "reference tree" sequences for phyl

SUBMITTER: Matsen FA 

PROVIDER: S-EPMC3797636 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature