Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish.

ABSTRACT: Zebrafish are becoming increasingly popular as an organism in which to model human disease and to study the effects of small molecules on complex physiological and pathological processes. Since larvae are no more than a few millimetres in length, and can live in volumes as small as 100 microliters, they are particularly amenable to high-throughput and high content compound screening in 96 well plate format. There is a growing literature providing evidence that many compounds show similar pharmacological effects in zebrafish as they do in mammals, and in particular humans. However, a major question regarding their utility for small molecule screening for neurological conditions is whether a molecule will reach its target site within the central nervous system. Studies have shown that Claudi

SUBMITTER: Fleming A 

PROVIDER: S-EPMC3797749 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature