MuPIT interactive: webserver for mapping variant positions to annotated, interactive 3D structures.

ABSTRACT: Mutation position imaging toolbox (MuPIT) interactive is a browser-based application for single-nucleotide variants (SNVs), which automatically maps the genomic coordinates of SNVs onto the coordinates of available three-dimensional (3D) protein structures. The application is designed for interactive browser-based visualization of the putative functional relevance of SNVs by biologists who are not necessarily experts either in bioinformatics or protein structure. Users may submit batches of several thousand SNVs and review all protein structures that cover the SNVs, including available functional annotations such as binding sites, mutagenesis experiments, and common polymorphisms. Multiple SNVs may be mapped onto each structure, enabling 3D visualization of SNV clusters and their relations

SUBMITTER: Niknafs N 

PROVIDER: S-EPMC3797853 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature