Prediagnostic plasma vitamin C and risk of gastric adenocarcinoma and esophageal squamous cell carcinoma in a Chinese population.

ABSTRACT:

Background

China has some of the highest incidence rates for gastric adenocarcinoma (GA) and esophageal squamous cell carcinoma (ESCC) in the world. Prospective studies suggested that vitamin C may reduce risks; however, associations are unclear because of limited sample size.

Objective

The objective was to examine the relation between prediagnostic plasma vitamin C and the risk of GA and ESCC.

Design

A case-cohort study was used to assess the association between prediagnostic plasma vitamin C and incidence of GA (n = 467) and ESCC (n = 618) in the General Population Nutrition Intervention Trial. With the use of multivariate Cox proportional hazards models, we estimated the HRs and 95% CIs. We also conducted a meta-analysis of the literature up to 1 October 2012 on th

SUBMITTER: Lam TK 

PROVIDER: S-EPMC3798080 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature