Maternal allergy is associated with surface-bound IgE on cord blood basophils.

ABSTRACT:

Background

The cell type(s) mediating the maternal influence on allergic disease in children remain unclear. We set out to define the relationship between maternal allergy and frequencies of cord blood (CB) basophils, and plasmacytoid dendritic cells (pDCs); to characterize surface-bound IgE and FcεRI expressions on these cells; and to investigate the association between maternal and CB serum IgE levels with surface-bound IgE and FcεRI expressions.

Methods

One hundred and three mother/infant dyads were recruited prenatally, and maternal allergic history was recorded. Maternal blood was collected prior to delivery, and CB was collected after birth. Flow cytometry was used to identify CB basophils and pDCs and to determine surface-bound IgE and FcεRI expressions.

Results

SUBMITTER: Matson AP 

PROVIDER: S-EPMC3798094 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature