Is JmjC oxygenase catalysis limited to demethylation?

ABSTRACT: Jobs on the side: Substrate selectivity studies indicate that members of the biomedically important JmjC demethylase family of histone N(ε)-methyllysine demethylases are capable of catalyzing the de-N-alkylation of groups other than N-methyl and can catalyze reactions that form stable hydroxylated products. The differences in binding preferences in this set of enzymes may be helpful in the design of selective inhibitors.

SUBMITTER: Hopkinson RJ 

PROVIDER: S-EPMC3798130 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature