Preclinical evaluation of zoledronate to maintain bone allograft and improve implant fixation in revision joint replacement.

ABSTRACT:

Background

Revision arthroplasty surgery is often complicated by loss of bone stock that can be managed by the use of bone allograft. The allograft provides immediate stability for the revision implant but may be resorbed, impairing subsequent implant stability. Bisphosphonates can delay allograft resorption. We hypothesized that zoledronate-impregnated allograft impacted around revision implants would improve implant fixation as characterized by mechanical push-out testing and histomorphometry.

Methods

Twenty-four axially pistoning micromotion devices were inserted bilaterally into the knees of twelve dogs according to our revision protocol. This produced a standardized revision cavity with a loose implant, fibrous tissue, and a sclerotic bone rim. Revision surgery was perf

SUBMITTER: Sorensen M 

PROVIDER: S-EPMC3798180 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature