Cumulative genetic risk predicts platinum/taxane-induced neurotoxicity.

ABSTRACT:

Purpose

The combination of a platinum and taxane are standard of care for many cancers, but the utility is often limited due to debilitating neurotoxicity. We examined whether single-nucleotide polymorphisms (SNP) from annotated candidate genes will identify genetic risk for chemotherapy-induced neurotoxicity.

Patients and methods

A candidate-gene association study was conducted to validate the relevance of 1,261 SNPs within 60 candidate genes in 404 ovarian cancer patients receiving platinum/taxane chemotherapy on the SCOTROC1 trial. Statistically significant variants were then assessed for replication in a separate 404 patient replication cohort from SCOTROC1.

Results

Significant associations with chemotherapy-induced neurotoxicity were identified and replicated for

SUBMITTER: McWhinney-Glass S 

PROVIDER: S-EPMC3798385 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature