Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design.

ABSTRACT: Human African trypanosomiasis is a neglected parasitic disease that is fatal if untreated. The current drugs available to eliminate the causative agent Trypanosoma brucei have multiple liabilities, including toxicity, increasing problems due to treatment failure and limited efficacy. There are two approaches to discover novel antimicrobial drugs--whole-cell screening and target-based discovery. In the latter case, there is a need to identify and validate novel drug targets in Trypanosoma parasites. The heat shock proteins (Hsp), while best known as cancer targets with a number of drug candidates in clinical development, are a family of emerging targets for infectious diseases. In this paper, we report the exploration of T. brucei Hsp83--a homolog of human Hsp90--as a drug target using mult

SUBMITTER: Pizarro JC 

PROVIDER: S-EPMC3798429 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature