Genetic polymorphisms of XRCC1, alcohol consumption, and the risk of colorectal cancer in Japan.

ABSTRACT:

Background

X-ray cross-complementing group 1 (XRCC1) polymorphisms affect DNA repair capacity and may therefore be of importance in colorectal carcinogenesis. Alcohol consumption, an important risk factor for colorectal cancer, may induce carcinogenesis through DNA damage caused by the toxic effects of alcohol or its metabolites. Therefore, we examined the associations of XRCC1 Arg399Gln, Arg280His, and Arg194Trp polymorphisms with colorectal cancer and the impact of the association between alcohol consumption and colorectal cancer risk.

Methods

This case-control study in Fukuoka, Japan including 685 cases and 778 controls. The cases were incident patients with histologically confirmed colorectal adenocarcinoma. The controls were randomly selected community subjects.

Resu

SUBMITTER: Yin G 

PROVIDER: S-EPMC3798582 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature