Serum hepatocyte growth factor and cancer mortality in an apparently healthy Japanese population.

ABSTRACT:

Background

In patients with cancer, hepatocyte growth factor (HGF) is elevated and is a predictor of prognosis. We investigated whether serum HGF was a predictive marker for cancer death in a population of community-dwelling Japanese.

Methods

We studied 1492 apparently healthy Japanese adults who underwent health examinations in 1999. Those who reported a history of liver disease or malignancy on a baseline questionnaire were excluded, and plasma HGF was measured in the remaining 1470 participants, who were followed periodically for 10 years. Multivariate proportional hazards regression was used to estimate cancer mortality.

Results

A total of 169 participants died during follow-up (61 from cancer, 32 from cerebrocardiovascular disease, and 76 from other diseases). Me

SUBMITTER: Otsuka M 

PROVIDER: S-EPMC3798633 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature