Relation of serum α- and γ-tocopherol levels to cardiovascular disease-related mortality among Japanese men and women.

ABSTRACT:

Background

There is limited evidence regarding the relationship between serum tocopherol levels and cardiovascular disease.

Methods

We conducted a nested case-control study as part of the Japan Collaborative Cohort Study for evaluation of cancer risk (JACC Study). Baseline serum samples were collected from 39 242 participants (age range, 40-79 years) between 1988 and 1990. During the 13-year follow-up, there were 530 stroke deaths (302 ischemic strokes and 210 hemorrhagic strokes) and 211 deaths from coronary heart disease. Controls were matched for sex, age, and area of residence.

Results

Serum α-tocopherol level was not associated with any type of cardiovascular death in men; however, in women, it was inversely associated with total stroke mortality and hemorrhagic

SUBMITTER: Nagao M 

PROVIDER: S-EPMC3798634 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature