Interactions between immunity, proliferation and molecular subtype in breast cancer prognosis.

ABSTRACT:

Background

Gene expression signatures indicative of tumor proliferative capacity and tumor-immune cell interactions have emerged as principal biology-driven predictors of breast cancer outcomes. How these signatures relate to one another in biological and prognostic contexts remains to be clarified.

Results

To investigate the relationship between proliferation and immune gene signatures, we analyzed an integrated dataset of 1,954 clinically annotated breast tumor expression profiles randomized into training and test sets to allow two-way discovery and validation of gene-survival associations. Hierarchical clustering revealed a large cluster of distant metastasis-free survival-associated genes with known immunological functions that further partitioned into three distinct imm

SUBMITTER: Nagalla S 

PROVIDER: S-EPMC3798758 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature