Uptake and transport of superparamagnetic iron oxide nanoparticles through human brain capillary endothelial cells.

ABSTRACT: The blood-brain barrier (BBB) formed by brain capillary endothelial cells (BCECs) constitutes a firm physical, chemical, and immunological barrier, making the brain accessible to only a few percent of potential drugs intended for treatment inside the central nervous system. With the purpose of overcoming the restraints of the BBB by allowing the transport of drugs, siRNA, or DNA into the brain, a novel approach is to use superparamagnetic iron oxide nanoparticles (SPIONs) as drug carriers. The aim of this study was to investigate the ability of fluorescent SPIONs to pass through human brain microvascular endothelial cells facilitated by an external magnet. The ability of SPIONs to penetrate the barrier was shown to be significantly stronger in the presence of an external magnetic force in

SUBMITTER: Thomsen LB 

PROVIDER: S-EPMC3798986 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature