Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain.

ABSTRACT: We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N-Tyr(cWTSI)). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background.

SUBMITTER: Ryder E 

PROVIDER: S-EPMC3799019 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature