Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls.

ABSTRACT: The integration of research on neuroimaging and pharmacogenetics holds promise for improving treatment for neuropsychiatric conditions. Neuroimaging may provide a more sensitive early measure of treatment response in genetically defined patient groups, and could facilitate development of novel therapies based on an improved understanding of pathogenic mechanisms underlying pharmacogenetic associations. This review summarizes progress in efforts to incorporate neuroimaging into genetics and treatment research on major psychiatric disorders, such as schizophrenia, major depressive disorder, bipolar disorder, attention-deficit/hyperactivity disorder, and addiction. Methodological challenges include: performing genetic analyses in small study populations used in imaging studies; inclusion of p

SUBMITTER: Falcone M 

PROVIDER: S-EPMC3799069 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature