Identification of cis-regulatory modules in promoters of human genes exploiting mutual positioning of transcription factors.

ABSTRACT: In higher organisms, gene regulation is controlled by the interplay of non-random combinations of multiple transcription factors (TFs). Although numerous attempts have been made to identify these combinations, important details, such as mutual positioning of the factors that have an important role in the TF interplay, are still missing. The goal of the present work is in silico mapping of some of such associating factors based on their mutual positioning, using computational screening. We have selected the process of myogenesis as a study case, and we focused on TF combinations involving master myogenic TF Myogenic differentiation (MyoD) with other factors situated at specific distances from it. The results of our work show that some muscle-specific factors occur together with MyoD within

SUBMITTER: Nandi S 

PROVIDER: S-EPMC3799424 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature