A combined omics study on activated macrophages--enhanced role of STATs in apoptosis, immunity and lipid metabolism.

ABSTRACT:

Background

Macrophage activation by lipopolysaccharide and adenosine triphosphate (ATP) has been studied extensively because this model system mimics the physiological context of bacterial infection and subsequent inflammatory responses. Previous studies on macrophages elucidated the biological roles of caspase-1 in post-translational activation of interleukin-1β and interleukin-18 in inflammation and apoptosis. However, the results from these studies focused only on a small number of factors. To better understand the host response, we have performed a high-throughput study of Kdo2-lipid A (KLA)-primed macrophages stimulated with ATP.

Results

The study suggests that treating mouse bone marrow-derived macrophages with KLA and ATP produces 'synergistic' effects that are not se

SUBMITTER: Dinasarapu AR 

PROVIDER: S-EPMC3799469 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature