IBMQ: a R/Bioconductor package for integrated Bayesian modeling of eQTL data.

ABSTRACT:

Motivation

Recently, mapping studies of expression quantitative loci (eQTL) (where gene expression levels are viewed as quantitative traits) have provided insight into the biology of gene regulation. Bayesian methods provide natural modeling frameworks for analyzing eQTL studies, where information shared across markers and/or genes can increase the power to detect eQTLs. Bayesian approaches tend to be computationally demanding and require specialized software. As a result, most eQTL studies use univariate methods treating each gene independently, leading to suboptimal results.

Results

We present a powerful, computationally optimized and free open-source R package, iBMQ. Our package implements a joint hierarchical Bayesian model where all genes and SNPs are modeled concurrent

SUBMITTER: Imholte GC 

PROVIDER: S-EPMC3799478 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature