Construction and accessibility of a cross-species phenotype ontology along with gene annotations for biomedical research.

ABSTRACT: Phenotype analyses, e.g. investigating metabolic processes, tissue formation, or organism behavior, are an important element of most biological and medical research activities. Biomedical researchers are making increased use of ontological standards and methods to capture the results of such analyses, with one focus being the comparison and analysis of phenotype information between species. We have generated a cross-species phenotype ontology for human, mouse and zebrafish that contains classes from the Human Phenotype Ontology, Mammalian Phenotype Ontology, and generated classes for zebrafish phenotypes. We also provide up-to-date annotation data connecting human genes to phenotype classes from the generated ontology. We have included the data generation pipeline into our continuous integ

SUBMITTER: Kohler S 

PROVIDER: S-EPMC3799545 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature